Nasa Spaceline Current Awareness List 1 013 August 19 2022 Space Life Science Research Results

                                                    NASA

Current SPACELINE awareness lists are distributed via a listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please direct any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, [email protected]. Call for Articles to Report to Weekly Lists: Authors at NASA Centers and NASA PIs — do you have an article that has recently been published or will be published in the coming weeks in a peer-reviewed journal that falls within the space life sciences field? If so, send it our way! Send your article to the email address listed above. Articles received by Wednesday will appear in this week’s list—articles received after Wednesday will appear next week. Documents sourced from NASA support: 1 Brojakowska A, Kour A, Thel MC, Park E, Bisserier M, Garikipati VNS, Hadri L, Mills PJ, Walsh K, Goukassian DA. Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts. Commun Biol. 17 Aug 2022, 5:828. PIs: K. Walsh, DA Goukassian Note: From the abstract: “With planned deep spaceflight and commercial spaceflight, gaps remain in addressing astronaut health risks. Multiple studies have shown associations between clonal expansion of hematopoietic cells with hematopoietic malignancies and cardiometabolic disease. This clonal expansion in the absence of overt hematopoietic disorders is called clonal hematopoiesis (CH) of indeterminate potential (CHIP). Using deep, error-corrected, targeted DNA sequencing, we screened for somatic mutations in CH driver genes in peripheral blood mononuclear cells isolated from de-identified blood samples collected from 14 astronauts flying Shuttle missions between 1998-2001. Journal Impact Score: 6,548 Funding: “We would like to thank the Lifetime Surveillance of Astronaut Health (LSAH) at NASA’s Johnson Space Center for their assistance with mission information and manuscript review. This work was supported by Translational Research Institute for Space Health award FIP0005 (to Dr. Goukassian), National Aeronautics and Space Administration Human Research Program Space Biology Element 80NSSC19K1079 (to Dr. Goukassian), and National Aeronautics and Space Administration Human Research Program Space Biology Element Grant 80NSSC21K0549 (to Drs. Goukassian and Walsh); 2 Buettmann EG, Goldscheitter GM, Hoppock GA, Friedman MA, Suva LJ, Donahue HJ. Similarities between disuse and age-related bone loss. J Bone Miner Res. 2022 Aug 37(8):1417-34. Review. PI: EG Buettmann, MA Friedman, HJ Donahue Journal Impact Factor: 6,390 Funding: “EGB and MAF were supported by the Translational Research Institute for Space Health through a NASA Cooperative Agreement (NNX16AO69A). HJD, GMG, and GAH were supported by NIH (NIAMS) grant R01 (AR068132), NASA grant 80NSSC18K1473, and National Space Biological Research Institute NSBRI/NASA grant, (MA02802). LJS is supported by R01HD102909 and 4R37 AA018282 from the NIH.” 3 Omer M, Ali H, Orlovskaya N, Ballesteros A, Cheong VS, Martyniak K, Wei F, Collins BE, Yarmolenko SN, Asiatico J, Kinzel M, Ngo C, Sankar J, Calder A, Gilbertson T, Meckmongkol T, Ghosh R , Coathup M. Omega-9 modifies viscoelasticity and increases bone strength and architecture in a mouse model fed a high-fat diet. Nutrients. 2022 Jul 31 14(15):3165. Note: This article is part of the “Fats” Section (https://www.mdpi.com/journal/nutrients/sections/Lipids) and can be downloaded online free of charge. Journal Impact Factor: 6.706 Funding: “This study was funded internally. The work of authors JA and CN was supported by the National Aeronautics and Space Administration [grant No. 80NSSC21M0309] issued through NASA’s Office of STEM Engagement.” 4 Stone KA, Mahoney SJ, Paryzek RA, Pitts L, Stastny SN, Mitchell SL, Downs ME, English KL, Hackney KJ. Interval blood flow restriction exercise rapidly improves muscle and cardiovascular health in adults with more than adequate protein intake. Acta Astronaut. 2022 Oct 199:224-31. Note: From the abstract: “Functional losses associated with spaceflight adversely affect astronaut health and mission success. Exercise combined with protein supplementation is a promising countermeasure. Blood flow restricted exercise (BFR) is an effective method, but the synergistic benefits when combined with protein supplementation are not clearly defined. The objectives of this investigation were to determine whether protein supplementation with a blend (eg, whey and casein) combined with BFR exercise favorably altered body composition, muscle function, and cardiovascular health during a short training program ». Journal Impact Factor: 2.954 Funding: M. Everett is affiliated with the NASA Johnson Space Center. 5 Smith KJ, Datta A, Burkhart C, Clark TK. Efficacy of galvanic vestibular stimulation as a display modality dissociated from self-orientation. Hum Factors. 2022 Aug 16 187208221119879. Online ahead of print. Journal Impact Score: 3,598 Funding: C. Burkhart is affiliated with the NASA Johnson Space Center. 6 Wang M, Yang Y, Min J, Song Y, Tu J, Mukasa D, Ye C, Xu C, Heflin N, McCune JS, Hsiai TK, Li Z, Gao W. A portable electrochemical biosensor for monitoring metabolites and nutrients. Nat Biomed Eng. August 15, 2022. PI: W. Gao Note: From the abstract: “Portable non-invasive biosensors for continuous monitoring of metabolites in sweat can detect some analytes at sufficiently high concentrations, typically during vigorous exercise, to produce a sufficient amount of biofluid. Here, we report the design and performance of a portable electrochemical biosensor for the continuous analysis, in sweat during exercise and at rest, of trace levels of multiple metabolites and nutrients, including all essential amino acids and vitamins.” This article can be downloaded online free of charge. Journal Impact Factor: 29,234 Funding: “This work was supported by National Institutes of Health grants R01HL155815, Office of Naval Research grants N00014-21-1-2483 and N00014-21-1-2845, the Translational Research Institute for Space Health through NASA NNX16AO69A, Agreement 80NSSC20M0167 , High Impact Pilot Research Award T31IP1666 and grant R01RG3746 from the Tobacco-related Disease Research Program, the Caltech-City of Hope Biomedical Initiative Pilot Grant, and the Rothenberg Innovation Initiative Program at the California Institute of Technology. JT was supported by a National Science Scholarship (NSS) from the Agency for Science Technology and Research (A*STAR) Singapore.” 7 Weber Boutros S, Unni VK, Raber J. An adaptive role for DNA double-strand breaks in hippocampus-dependent learning and memory. Int J Mol Sci. 2022 Jul 28, 23(15):8352. Review. PI: J. Raber/NSCOR Note: This article is part of the Research Topic “Molecular and Cellular Mechanisms of Brain Disease: The Hippocampus as a Hub” (https://www.mdpi.com/journal/ijms/special_issues/Hippocampus). This article can be downloaded online free of charge. Journal Impact Factor: 6.208 Funding: “This work was funded in part by an NSF Graduate Research Fellowship award, NASA NSCOR G-00066-4, R21 CA223461, R21 AG065914, RF1 AG059088, P30 AG066509, NS1037, F2022, NS1037, NS1037, NS101227. of Unni and Raber’.

Other documents of interest: 1 Belavy DL, Armbrecht G, Albracht K, Brisby H, Falla D, Scheuring R, Sovelius R, Wilke HJ, Rennerfelt K, Martinez-Valdes E, Arvanitidis M, Goell F, Braunstein B, Kaczorowski S, Karner V, Arora NK. Cervical spine and muscle adaptation after spaceflight and relation to hernia risk: Protocol from the Cervical in Space trial. BMC Musculoskeletal Disorder. August 13, 2022, 23:772. Note: ISS results. This article can be downloaded online free of charge. 2 Baran R, Wehland M, Schulz H, Heer M, Infanger M, Grimm D. Microgravity-related changes in bone mineral density and treatment options: A systematic review. Int J Mol Sci. 2022 Aug 3; 23(15): 8650. Review. Note: This article and the following article (Lichterfeld et al.) are part of the Topic “Translating Microgravity Research to Earth Application” (https://www.mdpi.com/topics/microgravity_research). Topic also includes articles from previous Current Awareness Lists #970 https://doi.org/10.3390/ijms22189997 and https://doi.org/10.3390/biomedicines9091205; #976 https://doi.org/10.3390/ijms222111759; #984 https://doi.org/10.3390/biomedicines10010059; and #989 https://doi.org/10.3390/biomedicines10020448. This article can be downloaded online free of charge. 3 Lichterfeld Y, Kalinski L, Schunk S, Schmakeit T, Feles S, Frett T,…

title: “Nasa Spaceline Current Awareness List 1 013 August 19 2022 Space Life Science Research Results Klmat” ShowToc: true date: “2022-12-04” author: “Jeanne Tith”

                                                    NASA

title: “Nasa Spaceline Current Awareness List 1 013 August 19 2022 Space Life Science Research Results Klmat” ShowToc: true date: “2022-10-25” author: “Angel Blevins”

                                                    NASA

title: “Nasa Spaceline Current Awareness List 1 013 August 19 2022 Space Life Science Research Results Klmat” ShowToc: true date: “2022-11-14” author: “Charlotte Alday”

                                                    NASA